What is binder? Discuss the effect of binder on formulation of Pharmaceutical product.
[6 marks]What is Disintegrant. Give the mechanism of and Factor affecting disintegrant on formulation of pharmaceutical product.
[5 marks]Write a note on effect of emulsifying and suspending agent on Pharmaceutical formulation.
[5 marks]How does particle size influence GI absorption of drugs? Explain with suitable example.
[6 marks]Writes the importance of physical forms in drug absorption. Explain with suitable example.
[5 marks]Explain the characteristics of Active transport process. Write their application in the development of formulation and administration of drugs.
[5 marks]Define Preformulation? Give its importance.
[6 marks]Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
[5 marks]Write notes on physicochemical parameters studied in preformulation study.
[5 marks]Explain world climatic zones as per ICH guidelines.
[6 marks]Discuss Brackating and Matrixing in brief
[5 marks]Discuss the factors affecting stability of drug.
[5 marks]What is BCS? Classify and give the significance of this system
[6 marks]Explain USP dissolution apparatus III, IV and Vwith diagram.
[5 marks]What is rvrvc? Describe In-vitro - In-vivo correlations levels. Q. 6 (a) Write a note on similarity factor and dissimilarity factor.
[6 marks]Explain: 1) Shelf life 2) Overages 3) Protein binding
[5 marks]Discuss pH —Partition hypothesis briefly with suitable examples. Enumerate the assumptions of this hypothesis.
[5 marks]Give a brief account on any one method of determining the bioavaibility.
[6 marks]Write a short notes on Biodegradable polymers.
[5 marks]Enumerates factors affecting dissolution of drug, discuss factors related to drug product formulation.
[5 marks]